Relugolix combo in fibroids
PICO
| Population | Adults randomised in trials registered on ClinicalTrials.gov for Fibroid. |
| Intervention | Relugolix (AACT-verified intervention name in each trial). |
| Comparator | Active comparator or placebo as registered on AACT. |
| Outcomes | Trial-declared primary outcome (AACT design_outcomes); event counts harvested from AACT outcome_measurements. |
| Design | Interventional RCTs (post-2010 start date), Phase 2/3 or Phase 3/4. |
Eligibility (6-gate audit)
- GATE-A — NCT exists in AACT 2026-04-12 snapshot.
- GATE-B — Drug pattern "relugolix" present in AACT
interventionsfor the NCT. - GATE-C — Condition pattern "fibroid" present in AACT
conditions. - GATE-D — Primary PMID's PubMed title or abstract mentions the drug or condition.
- GATE-E — AACT
baseline_countsreports ≥2 per-arm participant rows. - GATE-F — AACT
design_outcomesdeclares a primary outcome with measure text.
Audit verdict: VIABLE requires ≥3 trials passing all 6 gates (k≥3 — current standard for new audit-first builds). Older builds use k≥2.
Pre-specified primary outcomes (per trial)
- Percentage Of Participants Who Achieved A Menstrual Blood Loss (MBL) Volume Of < 80 mL And A ≥ 50% Reduction From Baseline MBL Volume With Relugolix Plus E2/NETA
- Percentage Of Participants Who Achieved Or Maintained An MBL Volume Of <80 Milliliters (mL) And At Least A 50% Reduction From Baseline MBL Volume At Week 52/End Of Treatment
- Percentage Of Participants Who Maintained MBL Volume Of <80 Milliliters (mL) At Week 76 During The Randomized Treatment Period
- Percentage of Participants With Total PBAC Score of <10 From Week 6 to 12
- Percentage of Participants With a Maximum NRS Score of 1 or Less During the 28 Days Before the Final Dose of Study Drug
Statistical methods
Inverse-variance random-effects pooling on the log-OR scale (Woolf estimator from AACT event counts), DerSimonian-Laird τ² with Hartung-Knapp-Sidik-Jonkman (HKSJ) variance correction and tk-1 critical value (Cochrane Handbook v6.5 conventions). Single-trial entries report Wald 95% CI on the log scale.
Search strategy
Source-of-truth: AACT 2026-04-12 snapshot from the Clinical Trials Transformation Initiative (CTTI). Auto-discovery query:
SELECT nct_id FROM interventions WHERE lower(name) LIKE '%relugolix%' INTERSECT SELECT nct_id FROM conditions WHERE lower(name) LIKE '%fibroid%'
PubMed bridge: NCBI E-utilities + idconv API to fetch primary publication PMID and abstract for each NCT.
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=relugolix+AND+fibroid+AND+RCT
Cross-checking: every NCT that survives intersection is verified to have a primary outcome declared in AACT design_outcomes AND a publication whose abstract mentions the drug or condition (GATE-D).
PRISMA-style screening
| Records identified (AACT × PubMed) | 8 |
| Records excluded (gate failure) | 2 |
| Records included (all 6 gates pass) | 6 |
Exclusions by first failing gate
| Gate | n |
|---|---|
| D_pmid_topic_match | 2 |
Screening is fully deterministic: every record is auto-flagged by the gate that first fails. No subjective inclusion/exclusion decisions are made — the 6 gates are an objective machine-checkable contract.
A Phase 3 Study to Evaluate the Efficacy and Safety of Relugolix (TAK-385) 40 mg Compared With Leuprorelin in the Treatment of Uterine Fibroids
Primary outcome (AACT): Percentage of Participants With Total PBAC Score of <10 From Week 6 to 12
| Events | No event | Total N | |
|---|---|---|---|
| Intervention | 1 | 138 | 139 |
| Control | 0 | 142 | 142 |
LIBERTY EXTENSION: Efficacy and Safety Extension Study of Relugolix in Women With Heavy Menstrual Bleeding Associated With Uterine Fibroids
Primary outcome (AACT): Percentage Of Participants Who Achieved Or Maintained An MBL Volume Of <80 Milliliters (mL) And At Least A 50% Reduction From Baseline MBL Volume At Week 52/End Of Treatment
| Events | No event | Total N | |
|---|---|---|---|
| Intervention | 86 | 77 | 163 |
| Control | 79 | 70 | 149 |
A Placebo-Controlled, Phase 3 Study of Relugolix (TAK-385) 40 mg in the Treatment of Pain Symptoms Associated With Uterine Fibroids
Primary outcome (AACT): Percentage of Participants With a Maximum NRS Score of 1 or Less During the 28 Days Before the Final Dose of Study Drug
| Events | No event | Total N | |
|---|---|---|---|
| Intervention | 57 | -24 | 33 |
| Control | 3 | 29 | 32 |
Study of Relugolix With Estradiol and Norethindrone Acetate in Women With Heavy Menstrual Bleeding Associated With Uterine Fibroids
Primary outcome (AACT): Percentage Of Participants Who Maintained MBL Volume Of <80 Milliliters (mL) At Week 76 During The Randomized Treatment Period
| Events | No event | Total N | |
|---|---|---|---|
| Intervention | 78 | 37 | 115 |
| Control | 15 | 98 | 113 |
LIBERTY 2: Efficacy & Safety Study of Relugolix in Women With Heavy Menstrual Bleeding Associated With Uterine Fibroids
Primary outcome (AACT): Percentage Of Participants Who Achieved A Menstrual Blood Loss (MBL) Volume Of < 80 mL And A ≥ 50% Reduction From Baseline MBL Volume With Relugolix Plus E2/NETA
| Events | No event | Total N | |
|---|---|---|---|
| Intervention | 71 | 55 | 126 |
| Control | 5 | 122 | 127 |
LIBERTY 1: Efficacy & Safety Study of Relugolix in Women With Heavy Menstrual Bleeding Associated With Uterine Fibroids
Primary outcome (AACT): Percentage Of Participants Who Achieved A Menstrual Blood Loss (MBL) Volume Of < 80 mL And A ≥ 50% Reduction From Baseline MBL Volume With Relugolix Plus E2/NETA
| Events | No event | Total N | |
|---|---|---|---|
| Intervention | 73 | 55 | 128 |
| Control | 18 | 114 | 132 |
Forest plot — per-trial OR + pooled estimate
Pooled estimate (REML-DL + HKSJ, Cochrane v6.5)
Leave-one-out
1. Heterogeneity
| τ² (DerSimonian-Laird) | 2.4618 |
| Q-statistic | 74.375 (df=3) |
| I² | 96.0% — considerable (>75%) |
| Method | REML-DL-HKSJ |
2. Prediction interval (Cochrane v6.5)
95% PI: 0.004 – 14836.997
tk-1 = 4.303 · √(τ² + SE²) = 1.763 (Cochrane Handbook v6.5, §10.10.4.3).
3. Egger's funnel asymmetry test
| Slope (bias) | -3.161 |
| Test verdict | p<0.05 (asymmetry) |
| Power note | recommended k≥10; current k=4 is exploratory. |
4. Leave-one-out sensitivity
6 omit-one re-runs (see Analysis section above).
5. PRISMA 2020 status
| Identification | AACT × PubMed intersection (deterministic) |
| Screening | 6-gate audit (machine-checkable) |
| Eligibility | k=6 trials passed all 6 gates |
| Included | k=4 with extractable event counts |
6. Risk of Bias (audit-first scope)
Audit-first builds do not apply RoB 2.0 domain coding — that requires full-text trial reading. The 6-gate audit gives an integrity floor (registration, drug, condition, outcomes, baseline counts, abstract concordance) but not a domain-level RoB verdict.
For RoB 2.0 coding, see the matching curated *_REVIEW.html for this topic if one exists in the flagship portfolio.
7. GRADE certainty (auto-derived)
Certainty: Low
Auto-derivation considers k and I² only; full GRADE requires RoB, indirectness, publication bias judgment, and effect-magnitude scoring (not applied in audit-first builds). Triggers: k=4 (imprecision); I²=96.0% (substantial heterogeneity).
8. Reproducibility fingerprint
sha256[:16] = 3d6c1c64d7c0682b
Bit-stable hash of {sorted NCT list, pooled OR + 95% CI}. Reproduce by re-running scripts/add_topic_autodiscover.py + generate_topic_html.py against the same AACT snapshot.
Audit-first build
This review was generated by the 6-gate audit-first pipeline after the 16-round portfolio cleanup. Every included trial was verified against AACT 2026-04-12 + PubMed at extraction time (not after).
- Full per-trial gate log:
outputs/new_topics/RELUGOLIX_FIBROIDS_AUTO_2.json - Methodology: FINAL_INTEGRITY_REPORT_V2.md
- Main index: RapidMeta portfolio
- AACT attribution: Clinical Trials Transformation Initiative (CTTI), snapshot 2026-04-12.
- PubMed attribution: NCBI E-utilities + idconv API.
Limits of this build
- Pool estimand is an OR derived from AACT event counts; the trial-published HR (where applicable) is not parsed from the PubMed abstract in the audit-first pipeline. The published-HR vs pooled-OR comparison is part of the full RapidMeta workbench for hand-curated reviews.
- Risk-of-bias (RoB-2) is not coded here — see the parent NMA review or the curated
*_REVIEW.htmlfor the same topic if one exists. - The 6 gates are necessary but not sufficient for a Cochrane-grade review — they are an integrity floor, not a ceiling.