CardioSynth

Living Cardiology Evidence Synthesis Engine

Browser-native · zero-dependency · provenance-tracked · ClinicalTrials.gov structured results only

How it works. Each tool is a single self-contained HTML file that runs entirely in your browser with no server, build step, or external dependency. Numbers pass fail-closed TruthCert validation; pooling uses DerSimonian–Laird random effects with HKSJ correction, validated against R metafor.

Phase 0 deliverable

Colchicine post-STEMI — master dashboard
Complete end-to-end living meta-analysis: harvest → extract → validate → pool → forest plot → narrative synthesis.

Core engine

MetaEngine
DS-L / HKSJ pooling, prediction intervals (tk-1), SVG forest plots.
TruthCert
10-validator fail-closed suite (arm swap, timepoint drift, outcome switching…).
Provenance Store
Audit trail and chain of custody for every extracted number.
Disagreement Queue
Two-agent extraction arbitration UI.
Update Engine
Living update protocol and SHA-256 synthesis versioning.

Harvesters

CT.gov Harvester
ClinicalTrials.gov API v2 search with cardiology filter.
Results Extractor
Structured results parser into standardized extraction objects.

Synthesis & bias

Bias Quantifier
Non-posting bias, ORBI, Egger's radial test, funnel plot (k≥10).
Portfolio Aggregator
Read-only cross-portfolio meta-view of independent living MA apps.