Colchicine post-STEMI: Living Evidence Synthesis

CardioSynth Phase 0.8 — Automated CT.gov harvesting, extraction, validation, and meta-analysis
v0.8.0 0 studies Not yet run

Full Pipeline

Click "Run Full Pipeline" to harvest, extract, validate, and synthesize evidence from ClinicalTrials.gov.

Harvest CT.gov
Extract Results
TruthCert Validate
Filter Cleared
Primary MA
Secondary MA
Cumulative MA
Bias Metrics
Provenance Hash
E156 Abstract
Ready to run.
Quick Start

This dashboard queries ClinicalTrials.gov for colchicine + myocardial infarction trials with posted results, extracts structured data, validates each study through 10 TruthCert validators, then runs DerSimonian-Laird HKSJ random-effects meta-analysis on the primary outcome (MACE or closest composite).

Search Strategy
🔎

Run the pipeline to see search strategy details.

PRISMA 2020 Flow Diagram
📈

Run the pipeline to generate the PRISMA flow diagram.

Inclusion / Exclusion Log
NCT ID Title Status Reason TruthCert Verdict Actions

Run the pipeline to see inclusion/exclusion decisions.

Cross-Validation: Registry vs Extracted
🔍

Run the pipeline to see cross-validation of extracted data against CT.gov registry values.

Living Update History
📅

Version history will appear after the first pipeline run.

WebR Independent Validation Optional
Evidence Map
NCT ID Trial Name N Year Sponsor TruthCert Weight%
Robustness Check Dashboard

Run the pipeline to see robustness checks.

Primary Synthesis: MACE (Major Adverse Cardiovascular Events)
📊

Run the pipeline to generate the forest plot.

Synthesis Statistics

No data yet.

MCID Threshold Analysis

Run the pipeline to see MCID analysis.

Sensitivity Scenario Analysis

Run the pipeline to see sensitivity scenarios.

Leave-One-Out Sensitivity

No data yet.

📈

Run the pipeline to see secondary outcome analyses.

Cumulative Meta-Analysis (by Primary Completion Date)
📈

Run the pipeline to generate the cumulative analysis.

Cumulative Data

No data yet.

Evidence Velocity & Maturity

Run the pipeline to see evidence velocity metrics.

Non-Posting Bias

No data yet.

ORBI (Outcome Registration Bias Index)

No data yet.

Funnel Plot

No data yet.

Egger's Test (Radial)

No data yet.

Provenance Bundle

The provenance bundle contains all ExtractionObjects, TruthCert reports, synthesis results, and timestamps for full audit trail reproducibility.

SHA-256 Hash
Not yet computed
Bundle Timestamp
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Studies
0
Awaiting pipeline run...
E156 Micro-Paper Abstract
📝

Run the pipeline to auto-generate the E156 abstract.

Visual Abstract
📄

Run the pipeline to generate the Visual Abstract.

Manuscript: Methods & Results Paragraphs
📝

Run the pipeline to generate manuscript text.

GRADE Summary of Findings Table

Run the pipeline to generate the GRADE SoF table.

Scientific Output: NYT-Style Narrative Report
📰

Run the pipeline to generate the narrative report.