TSA Calculator

Studies (in order)

Data CSV: label, estimate, SE Studies are cumulated in the order given. Effect size should be logOR / logRR / MD / SMD.

Information size RIS source

Target effect δ α (two-sided) Power (1-β)

Manual RIS (Σ 1/SE² at target) Diversity adjustment D (≥1, from random-effects) RIS is multiplied by D. Use 1.0 for fixed-effect plan.

Display Plot title

O'Brien-Fleming boundary z_k = z_α/2/√t_k where t_k is the information fraction (per advanced-stats.md). Non-binding futility is shown if enabled.