Mahmood Ahmad
Tahir Heart Institute
author@example.com

Protocol: CT.gov U.S. Versus Global Gap

This protocol groups eligible older closed interventional ClinicalTrials.gov studies into four geography buckets using recorded study-country locations: U.S. only, U.S. plus non-U.S., no U.S., and no named country. Primary outputs compare two-year no-results rates, ghost-protocol rates, and fully visible shares across those buckets, with a secondary sponsor-class contrast for industry, NIH, and other sponsors. The aim is to test whether cross-border participation corresponds to a materially different public registry surface than domestic-only or non-U.S.-only portfolios. Because the buckets come from recorded locations, the analysis measures registry geography rather than verified enrollment share, sponsor domicile, or legal obligation.

Outside Notes

Type: protocol
Primary estimand: 2-year no-results rate across U.S./non-U.S. geography buckets among eligible older CT.gov studies
App: CT.gov U.S. Versus Global Gap dashboard
Code: https://github.com/mahmood726-cyber/ctgov-us-vs-global-gap
Date: 2026-03-29
Validation: FULL REGISTRY RUN

References

1. ClinicalTrials.gov API v2. National Library of Medicine. Accessed March 29, 2026.
2. Zarin DA, Tse T, Williams RJ, Carr S. Trial reporting in ClinicalTrials.gov. N Engl J Med. 2016;375(20):1998-2004.
3. DeVito NJ, Bacon S, Goldacre B. Compliance with legal requirement to report clinical trial results on ClinicalTrials.gov: a cohort study. Lancet. 2020;395(10221):361-369.

AI Disclosure

This work represents a compiler-generated evidence micro-publication built from structured registry data and deterministic summary code. AI was used as a constrained coding and drafting assistant for interface generation, packaging, and prose refinement, not as an autonomous author. The analytical choices, interpretation, and final outputs were reviewed by the author, who takes responsibility for the content.