Mahmood Ahmad
Tahir Heart Institute
author@example.com

Protocol: CT.gov Trial-Architecture Gap

This protocol groups eligible older closed interventional ClinicalTrials.gov studies by arm-group count and intervention count. Primary outputs compare two-year no-results rates, ghost-protocol rates, and hiddenness scores across simple and complex architectures, with a secondary phase-specific arm-count contrast. The aim is to test whether simpler protocol structure corresponds to a more visible public record. Because arm and intervention counts are registry structure fields, the project measures declared architecture rather than full protocol complexity.

Outside Notes

Type: protocol
Primary estimand: 2-year no-results rate across arm-group buckets among eligible older CT.gov studies
App: CT.gov Trial-Architecture Gap dashboard
Code: https://github.com/mahmood726-cyber/ctgov-trial-architecture-gap
Date: 2026-03-29
Validation: FULL REGISTRY RUN

References

1. ClinicalTrials.gov API v2. National Library of Medicine. Accessed March 29, 2026.
2. Zarin DA, Tse T, Williams RJ, Carr S. Trial reporting in ClinicalTrials.gov. N Engl J Med. 2016;375(20):1998-2004.
3. DeVito NJ, Bacon S, Goldacre B. Compliance with legal requirement to report clinical trial results on ClinicalTrials.gov: a cohort study. Lancet. 2020;395(10221):361-369.

AI Disclosure

This work represents a compiler-generated evidence micro-publication built from structured registry data and deterministic summary code. AI was used as a constrained coding and drafting assistant for interface generation, packaging, and prose refinement, not as an autonomous author. The analytical choices, interpretation, and final outputs were reviewed by the author, who takes responsibility for the content.