Mahmood Ahmad
Tahir Heart Institute
author@example.com

Protocol: CT.gov Actual-Field Discipline

This protocol groups eligible older closed interventional ClinicalTrials.gov studies by three closed-study actual-field indicators: primary completion, completion, and enrollment. Primary outputs compare two-year no-results rates, ghost-protocol rates, and fully visible shares for actual-field present versus missing groups, with a secondary final-status contrast on missing-actual rates. The aim is to test whether closed-study actual-field discipline is a strong structural warning sign for opacity. Because the indicators come from registry date and count types, the project measures documented actual-field discipline rather than externally audited sponsor knowledge.

Outside Notes

Type: protocol
Primary estimand: 2-year no-results rate across actual-field discipline groups among eligible older CT.gov studies
App: CT.gov Actual-Field Discipline dashboard
Code: https://github.com/mahmood726-cyber/ctgov-actual-field-discipline
Date: 2026-03-29
Validation: FULL REGISTRY RUN

References

1. ClinicalTrials.gov API v2. National Library of Medicine. Accessed March 29, 2026.
2. Zarin DA, Tse T, Williams RJ, Carr S. Trial reporting in ClinicalTrials.gov. N Engl J Med. 2016;375(20):1998-2004.
3. DeVito NJ, Bacon S, Goldacre B. Compliance with legal requirement to report clinical trial results on ClinicalTrials.gov: a cohort study. Lancet. 2020;395(10221):361-369.

AI Disclosure

This work represents a compiler-generated evidence micro-publication built from structured registry data and deterministic summary code. AI was used as a constrained coding and drafting assistant for interface generation, packaging, and prose refinement, not as an autonomous author. The analytical choices, interpretation, and final outputs were reviewed by the author, who takes responsibility for the content.